you stepped in the wrong place " says Topol. )Califf and Topol's collaboration led to a landmark study, codenamed GUSTO, of 'clot busting' drugs given to heart attack patients to break up blood clots. The study swelled to 41,000 patients from more than a thousand hospitals with patients enrolled from every continent except Antarctica, says Topol. The trial showed that a clot buster made by Genentech of South San Francisco, California, reduced the risk of death following heart attack, and led to a change in treatment guidelines. Califf went on to found and lead the Duke Clinical Research Institute, which now .
"He is a big get for the FDA," says Ellen Sigal, founder and chair of Friends of Cancer Research, a think tank and advocacy group in Washington DC. "People are very excited about him coming. "Landmark trialSigal and others are enthused about Califf's wide experience in running clinical trials at Duke, where he is currently vice chancellor of clinical and translational research. His earliest foray into large clinical trials was in the 1980s, at the behest of friend and fellow cardiologist Eric Topol, now at the Scripps Research Institute in La Jolla, California. The two met on medical fellowships at the University of California, San Francisco, where they played football in Kezar Stadium or, as they affectionately called it, dog shit field.
fell silent to listen. "He doesn't say things unless he has something to say," says Pitts. "He has a reputation for not Puma X Ueg Court Play Boot
past week, people have had plenty to say about Califf. When FDA commissioner Margaret Hamburg announced on 5 February that she would resign in March, it rekindled familiar rumours that Califf appointed a deputy commissioner at the agency late last Puma Ignite Evoknit Weeknd month was being groomed to take her place. Califf, a soft spoken Southerner with a passion for improving clinical trials, will take a leave of absence from Duke University in Durham, North Carolina, to step into the deputy commissioner post at the end of February.
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